Dapivirine ( TMC120 )

Catalog No. M13709 CAS No. 244767-67-7

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Product Name

Dapivirine
Note

Research use only, not for human use.
Brief Description

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM.
Description

Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3.
Synonyms

TMC120
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV reverse transcriptase
Research Area

Infection
Indication

——

CAS Number

244767-67-7
Formula Weight

329.40
Molecular Formula

C20H19N5
Purity

>98%(HPLC)
Solubility

DMSO: 34 mg/mL (103.21 mM)
SMILES

N#CC1=CC=C(NC2=NC=CC(NC3=C(C)C=C(C)C=C3C)=N2)C=C1
Chemical Name

4-[[4-[(2,4,6-Trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile

1.Van Herrewege Y, et al. Antimicrob Agents ChemOthers, 2004, 48(1), 337-339.

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