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DVR-01

CAS No. 330461-34-2

DVR-01( DVR 01 | DVR01 | 3-(azepan-1-ylsulfonyl)-N-benzyl-4-chlorobenzamide )

Catalog No. M27873 CAS No. 330461-34-2

DVR-01 is an HBV capsid inhibitor and can be used in studies about the treatment of Hepatitis B virus (HBV) infection and related conditions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DVR-01
  • Note
    Research use only, not for human use.
  • Brief Description
    DVR-01 is an HBV capsid inhibitor and can be used in studies about the treatment of Hepatitis B virus (HBV) infection and related conditions.
  • Description
    DVR-01 is an HBV capsid inhibitor and can be used in studies about the treatment of Hepatitis B virus (HBV) infection and related conditions.
  • In Vitro
    DVR-01 (0-10 μM; 4 d) inhibits HBV in human hepatoma cells with EC50 values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively.DVR-01 (0.156-10 μM; 2 d) selectively disrupts the pgRNA encapsidation by HBV.DVR-01 (3 d) shows antiviral activity against hepadnaviruses in human hepatoma cells with EC50s of 2.899, ＞10 and ＞25 μM for HBV, WHV and DHBV, respectively.DVR-01 (0.0097-10 μM; 2 d) shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.899, 3.273, 3.180, 2.752, 2.567 and 2.403 μM for wt, rtL180 M/rtM204V, rtA181V, rtN236T, rtM204I and rtL180 M/rtM204V/rtT184G/rtS202I, respectively.
  • In Vivo
    ——
  • Synonyms
    DVR 01 | DVR01 | 3-(azepan-1-ylsulfonyl)-N-benzyl-4-chlorobenzamide
  • Pathway
    Microbiology/Virology
  • Target
    HBV
  • Recptor
    Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    330461-34-2
  • Formula Weight
    406.93
  • Molecular Formula
    C20H23ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1ccc(cc1S(=O)(=O)N1CCCCCC1)C(=O)NCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Simoni S, et al. Enantioselective Metabolism of Chiral 3-Phenylbutyric Acid, an Intermediate of Linear Alkylbenzene Degradation, by Rhodococcus rhodochrous PB1. Appl Environ Microbiol. 1996 Mar;62(3):749-55.
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