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DUPA

CAS No. 302941-52-2

DUPA ( (2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid; N,N''-Carbonylbis[L-glutamic acid] )

Catalog No. M27072 CAS No. 302941-52-2

DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 Get Quote
5MG 53 Get Quote
10MG 87 Get Quote
25MG 158 Get Quote
50MG 267 Get Quote
100MG 410 Get Quote
200MG 591 Get Quote
500MG 888 Get Quote
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Biological Information

  • Product Name
    DUPA
  • Note
    Research use only, not for human use.
  • Brief Description
    DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
  • Description
    DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.(In Vitro):After binding to a DUPA-drug conjugate, PSMA internalizes, unloads the conjugate, and returns to the surface.(In Vivo):As determined by loss of body weight and death of treated mice,DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity.
  • Synonyms
    (2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid; N,N''-Carbonylbis[L-glutamic acid]
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    20S proteasome
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    302941-52-2
  • Formula Weight
    320.3
  • Molecular Formula
    C11H16N2O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@](CCC(O)=O)(NC(=O)N[C@@]([H])(CCC(O)=O)C(O)=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4;113(23):5927-37.
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