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DS-437
CAS No. 1674364-87-4
DS-437 ( DS437;DS 437 )
Catalog No. M12556 CAS No. 1674364-87-4
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDS-437
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NoteResearch use only, not for human use.
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Brief DescriptionDS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7.
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DescriptionDS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases; inhibits methylation of full-length histone 4 by PRMT5-MEP50 with an IC50 of 37 ± 1.2 μM in a biochemical assay; inhibits symmetrical dimethylation of PRMT5 substrates in cells.
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SynonymsDS437;DS 437
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number1674364-87-4
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Formula Weight397.45
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Molecular FormulaC15H23N7O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NCCSC[C@H]1O[C@@H](N2C=NC3=C(N=CN=C23)N)[C@@H]([C@@H]1O)O)NCC
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Chemical Name1-[2-[[(2S,3R,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smil D, et al. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.
molnova catalog
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