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DS-1971a

CAS No. 1450595-86-4

DS-1971a ( —— )

Catalog No. M28831 CAS No. 1450595-86-4

DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DS-1971a
  • Note
    Research use only, not for human use.
  • Brief Description
    DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
  • Description
    DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.(In Vitro):DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7.(In Vivo):DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1450595-86-4
  • Formula Weight
    465.9
  • Molecular Formula
    C20H21ClFN5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cn1nccc1[C@@H](CCCC1)[C@H]1Oc(cc(c(S(Nc1ncncc1)(=O)=O)c1)F)c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yu S S , Yu D Q , Liang X T . Triterpenoid saponins from the roots of Aralia spinifolia.[J]. Journal of Natural Products, 1994, 57(7):978.
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