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DMXAA

CAS No. 117570-53-3

DMXAA ( ASA-404;Vadimezan )

Catalog No. M10596 CAS No. 117570-53-3

A vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM; activates STING dependent innate immune pathways.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 In Stock
5MG 73 In Stock
10MG 99 In Stock
25MG 215 In Stock
50MG 389 In Stock
100MG 428 In Stock
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Biological Information

  • Product Name
    DMXAA
  • Note
    Research use only, not for human use.
  • Brief Description
    A vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM; activates STING dependent innate immune pathways.
  • Description
    A vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM; activates STING dependent innate immune pathways.
  • Synonyms
    ASA-404;Vadimezan
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    DT-diaphorase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    117570-53-3
  • Formula Weight
    282.29
  • Molecular Formula
    C17H14O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6.5 mg/mL
  • SMILES
    O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
  • Chemical Name
    9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Phillips RM. Biochem Pharmacol. 1999 Jul 15;58(2):303-10.
2. Prantner D, et al. J Biol Chem. 2012 Nov 16;287(47):39776-88.
3. Shirey KA, et al. J Leukoc Biol. 2011 Mar;89(3):351-7.
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