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DIMP53-1
CAS No. ——
DIMP53-1( —— )
Catalog No. M17082 CAS No. ——
A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDIMP53-1
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.
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DescriptionA novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM; causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis; shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight408.501
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Molecular FormulaC27H24N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N2[C@@](OC[C@@H]2CC3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5)(C)C6=C1C=CC=C6
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Chemical Name(3S,9bR)-3-((1-benzyl-1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.
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