Cart
sales@molnova.com
Home - Products - Apoptosis - MDM2-p53 - DIMP53-1

DIMP53-1

CAS No. ——

DIMP53-1( —— )

Catalog No. M17082 CAS No. ——

A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    DIMP53-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.
  • Description
    A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM; causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis; shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    408.501
  • Molecular Formula
    C27H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N2[C@@](OC[C@@H]2CC3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5)(C)C6=C1C=CC=C6
  • Chemical Name
    (3S,9bR)-3-((1-benzyl-1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Brigimadlin

    Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase

  • MD-224

    MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.

  • P53R3

    P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays.

Sign In Join Free