DIMP53-1

CAS No. ——

DIMP53-1( —— )

Catalog No. M17082 CAS No. ——

A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    DIMP53-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.
  • Description
    A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM; causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis; shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    408.501
  • Molecular Formula
    C27H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N2[C@@](OC[C@@H]2CC3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5)(C)C6=C1C=CC=C6
  • Chemical Name
    (3S,9bR)-3-((1-benzyl-1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.
molnova catalog
related products
  • Brigimadlin

    Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase

  • MD-224

    MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.

  • P53R3

    P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays.