Brigimadlin

CAS No. 2095116-40-6

Brigimadlin( —— )

Catalog No. M36316 CAS No. 2095116-40-6

Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 410 Get Quote
5MG 561 Get Quote
10MG 846 Get Quote
25MG 1398 Get Quote
50MG 1822 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Brigimadlin
  • Note
    Research use only, not for human use.
  • Brief Description
    Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
  • Description
    Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor, preventing MDM-2 from negatively regulating the tumor suppressor p53. Brigimadlin can be used for antineoplastic research.
  • In Vitro
    Cell Viability Assay Cell Line:BT48, BT50, BT67, BT69, BT89, BT94 Concentration:0-10 nM Incubation Time:48 h Result:IC50: 58.5, 21.1, 37.9, 89.8, 16.7, 46.8 pM.Western Blot Analysis Cell Line:BT48, BT67, BT73 cells Concentration:0-50 nM Incubation Time:48 h Result:Upregulated p21 and PUMA, and increased cleaved PARP level.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    Mdm2 | p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2095116-40-6
  • Formula Weight
    591.46
  • Molecular Formula
    C31H25Cl2FN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.
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