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Brigimadlin

CAS No. 2095116-40-6

Brigimadlin( —— )

Catalog No. M36316 CAS No. 2095116-40-6

Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Brigimadlin
  • Note
    Research use only, not for human use.
  • Brief Description
    Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase
  • Description
    Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor, preventing MDM-2 from negatively regulating the tumor suppressor p53. Brigimadlin can be used for antineoplastic research.
  • In Vitro
    Cell Viability Assay Cell Line:BT48, BT50, BT67, BT69, BT89, BT94 Concentration:0-10 nM Incubation Time:48 h Result:IC50: 58.5, 21.1, 37.9, 89.8, 16.7, 46.8 pM.Western Blot Analysis Cell Line:BT48, BT67, BT73 cells Concentration:0-50 nM Incubation Time:48 h Result:Upregulated p21 and PUMA, and increased cleaved PARP level.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    Mdm2 | p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2095116-40-6
  • Formula Weight
    591.46
  • Molecular Formula
    C31H25Cl2FN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gollner Andreas, et al. Preparation of spiroindolepyrrolidinone derivatives for use as MDM2-p53 inhibitors: World Intellectual Property Organization, WO2017060431. 2017-04-13.
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