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DDX3-IN-16d

CAS No. 1919828-83-3

DDX3-IN-16d( —— )

Catalog No. M13009 CAS No. 1919828-83-3

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DDX3-IN-16d
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3).
  • Description
    A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses; shows a broad spectrum of antiviral activity with EC50 of 0.97-16.5 uM (HIV, HCV, DENV, and WNV), retaines full activity against HIV drug-resistant strains (EC50<1 uM); exhibts a good safety profile and bioavailability in rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1919828-83-3
  • Formula Weight
    307.357
  • Molecular Formula
    C17H17N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 406.70 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(NC1=CC=C(N2N=NC(C)=C2)C=C1)NC3=CC=CC=C3C
  • Chemical Name
    1-(4-(4-Methyl-1H-1,2,3-triazol-1-yl)phenyl)-3-o-tolylurea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brai A, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93.
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