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DDX3-IN-16d

CAS No. 1919828-83-3

DDX3-IN-16d( —— )

Catalog No. M13009 CAS No. 1919828-83-3

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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100MG	1971	Get Quote
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Biological Information

Product Name

DDX3-IN-16d
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3).
Description

A small molecule inhibitor (IC50=0.3 uM) of DEAD-box polypeptide 3 (DDX3), a human host factor required for the replication of several DNA and RNA viruses; shows a broad spectrum of antiviral activity with EC50 of 0.97-16.5 uM (HIV, HCV, DENV, and WNV), retaines full activity against HIV drug-resistant strains (EC50<1 uM); exhibts a good safety profile and bioavailability in rats.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

——
Indication

——

Chemical Information

CAS Number

1919828-83-3
Formula Weight

307.357
Molecular Formula

C17H17N5O
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 406.70 mM; H2O : < 0.1 mg/mL
SMILES

O=C(NC1=CC=C(N2N=NC(C)=C2)C=C1)NC3=CC=CC=C3C
Chemical Name

1-(4-(4-Methyl-1H-1,2,3-triazol-1-yl)phenyl)-3-o-tolylurea

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Brai A, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93.

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