D211 ( S,S)-D211;D-211 )

Catalog No. M13086 CAS No. 1971075-99-6

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Product Name

D211
Note

Research use only, not for human use.
Brief Description

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.
Description

A novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs); displays picomolar potency against AML cancer cell lines.
Synonyms

S,S)-D211;D-211
Pathway

Antibody Drug Conjugates (ADC)
Target

ADC Cytotoxin
Recptor

ADC Cytotoxin
Research Area

——
Indication

——

CAS Number

1971075-99-6
Formula Weight

656.74
Molecular Formula

C39H36N4O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C2=CC(OC)=C(OCCCOC3=C(OC)C=C(C4=O)C(N=C[C@@]5([H])N4CC6=C(C=CC=C6)C5)=C3)C=C2N=C[C@@]7([H])N1CC8=C(C=CC=C8)C7
Chemical Name

(6aS,6a'S)-3,3'-(propane-1,3-diylbis(oxy))bis(2-methoxy-7,12-dihydrobenzo[5,6][1,4]diazepino[1,2-b]isoquinolin-14(6aH)-one)

1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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