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D-156844
CAS No. 1005501-84-7
D-156844( —— )
Catalog No. M10049 CAS No. 1005501-84-7
D156844 is a potent SMN2 inducer and DcpS inhibitor; highly potent at activating SMN2 promoter activity with EC50 of 4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameD-156844
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NoteResearch use only, not for human use.
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Brief DescriptionD156844 is a potent SMN2 inducer and DcpS inhibitor; highly potent at activating SMN2 promoter activity with EC50 of 4 nM.
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DescriptionD156844 is a potent SMN2 inducer and DcpS inhibitor; highly potent at activating SMN2 promoter activity with EC50 of 4 nM; increases SMN expression in neonatal mouse neural tissues, delays motor neuron loss at PND11 and ameliorates the motor phenotype of SMNDelta7 SMA mice; orally active.Spinal Muscular Atrophy (SMA)Preclinical.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetSMN2
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RecptorSMN2
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Research Area——
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Indication——
Chemical Information
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CAS Number1005501-84-7
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Formula Weight381.455
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Molecular FormulaC21H24FN5O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-((1-(2-fluorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Butchbach ME, et al. Hum Mol Genet. 2010 Feb 1;19(3):454-67.
2. Butchbach ME, et al. Exp Neurol. 2014 Jun;256:1-6.
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