Cycloheximide

Research use only, not for human use.

Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor.

Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively; block the elongation phase of eukaryotic translation, binds the ribosome and inhibits eEF2-mediated translocation; impairs memory more as footshock intensity increases, enhances memory in an inverted-U dose-response manner at low dose; also sensitizes COLO 205 cells to TNF-alpha-induced programmed cell death.

Naramycin A;Actidione

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA/RNA Synthesis

Infection

——

66-81-9

281.35

C15H23NO4

>98% (HPLC)

DMSO: >33 mg/mL; H2O: 20 mg/mL (Need ultrasonic and warming)

O=C(CC(C[C@H]([C@H]1C([C@@H](C)C[C@H](C)C1)=O)O)C2)NC2=O

2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-

(-20℃)

With Ice Pack

≥ 2 years