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Cyclogalegenol
CAS No. 78574-94-4
Cyclogalegenol( Astramembrangenin )
Catalog No. M20292 CAS No. 78574-94-4
Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 50 | In Stock |
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| 25MG | 73 | In Stock |
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| 50MG | 107 | In Stock |
|
| 100MG | 159 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCyclogalegenol
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NoteResearch use only, not for human use.
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Brief DescriptionAstramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.
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DescriptionAstramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.
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In VitroCycloastragenol (0.03-3 μM; 24-72 hours) promotes viability, osteoblastic differentiation, and mineralization in MC3T3-E1 cells.
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In VivoCycloastragenol (5, 10, 20 mg/kg) is injected intraperitoneally at the onset of reperfusion, 12 h later and then twice daily for up to three days. Cycloastragenol dose-dependently reduces brain infarct volume, significantly ameliorated functional deficits, and prevents neuronal cell loss in middle cerebral artery occlusion (MCAO) mice. Cycloastragenol suppresses the mRNA expression of pro-inflammatory cytokines, including TNF-α and IL-1β, and inhibits the activation of microglia and astrocytes in the ischemic brain.
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SynonymsAstramembrangenin
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorCREB
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Research Area——
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Indication——
Chemical Information
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CAS Number78574-94-4
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Formula Weight490.72
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Molecular FormulaC30H50O5
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Purity>98% (HPLC)
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SolubilityDMSO:98 mg/mL (199.71 mM)
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SMILES[H][C@@]1([C@@H](O)C[C@@]2(C)[C@]3([H])C[C@H](O)[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O)C4(C)C)[C@@]1(C)CC[C@H](O1)C(C)(C)O
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Chemical Name(2aR3R4S5aS5bS7S7aR9S11aR12aS)-3-((2R5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a5a88-tetramethyltetradecahydro-1H12H-cyclopenta[a]cyclopropa[e]phenanthrene-479-triol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sun C Jiang M Zhang L et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model[J]. Immunopharmacology and Immunotoxicology 2017 39(3):131-139.
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