ZL0580

Research use only, not for human use.

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

Cell Viability Assay Cell Line:HIV-infected human CD4+ T cells.Concentration:0-8 μM.Incubation Time:2 days.Result:Suppress HIV in primary CD4+ T cell.Single treatment (8 μM) led to almost completed loss of productive HIV infection in CD4+ T cells.RT-PCR Cell Line:PBMCs of viremic HIV-infected individuals.Concentration:8 μM.Incubation Time:2 days.Result:Suppresses HIV transcription ex vivo in PBMCs of viremic HIV-infected individuals.Cell Cytotoxicity Assay Cell Line:J-Lat cells. Concentration:0-80 μM.Incubation Time:1 and 3 days.Result:Did not cause significant cell death at concentrations below 40 μM.Treatment of J-Lat cells with ZL0580 (10 μM) also did not cause significant cell death on days 2, 7, and 14 compared with NC in both PMA-activated and unstimulated cells.

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Chromatin/Epigenetic

Epigenetic Reader Domain

BRD4|HIV

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2377151-10-3

532.53

C25H23F3N4O4S

>98% (HPLC)

DMSO:250 mg/mL (469.46 mM; Need ultrasonic)

C1C[C@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F)C(=O)NC4=CC=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years