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Home - Products - Cell Cycle/DNA Damage - Topoisomerase - Cu(II)-Elesclomol

Cu(II)-Elesclomol

CAS No. 1224195-72-5

Cu(II)-Elesclomol( —— )

Catalog No. M37545 CAS No. 1224195-72-5

Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which selectively transports copper to mitochondria.Cu(II)-Elesclomol has anticancer activity, inhibits the growth of human leukemia K562 cells, and induces cell-cycle arrest, and is used in the study of leukemias.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cu(II)-Elesclomol
  • Note
    Research use only, not for human use.
  • Brief Description
    Cu(II)-Elesclomol is a complex formed by the anticancer agent Elesclomol and Cu(II), which selectively transports copper to mitochondria.Cu(II)-Elesclomol has anticancer activity, inhibits the growth of human leukemia K562 cells, and induces cell-cycle arrest, and is used in the study of leukemias.
  • Description
    Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces apoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topoisomerase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1224195-72-5
  • Formula Weight
    462.05
  • Molecular Formula
    C19H18CuN4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 6.67 mg/mL (14.44 mM; Ultrasonic (<80°C)
  • SMILES
    O=C1[N-]2N(C(=[S][Cu+2]32[S]=C(C=4C=CC=CC4)N([N-]3C(=O)C1)C)C=5C=CC=CC5)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brian B Hasinoff, et al.Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76.?
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