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Contezolid

CAS No. 1112968-42-9

Contezolid ( MRX I )

Catalog No. M10415 CAS No. 1112968-42-9

Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Contezolid
  • Note
    Research use only, not for human use.
  • Brief Description
    Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
  • Description
    Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL; demonstrates the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.Bacterial Infection Phase 3 Clinical
  • Synonyms
    MRX I
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1112968-42-9
  • Formula Weight
    408.34
  • Molecular Formula
    C18H15F3N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1CCN(C2=C(F)C=C(N3C(O[C@@H](CNC4=NOC=C4)C3)=O)C(F)=C2F)C=C1
  • Chemical Name
    1-{2,3,6-trifluoro-4-[(5S)-5-{[(1,2-oxazol-3-yl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl]phenyl}-2,3-dihydropyridin-4(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li CR, et al. Antimicrob Agents Chemother. 2014;58(4):2418-21.
2. Gordeev MF, et al. J Med Chem. 2014 Jun 12;57(11):4487-97.
3. Meng J, et al. Drug Metab Dispos. 2015 May;43(5):646-59.
4. Eckburg PB, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02181-16.
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