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Cilobradine
CAS No. 186097-54-1
Cilobradine( DK-AH 269 | DKAH-269 )
Catalog No. M12874 CAS No. 186097-54-1
A hyperpolarization-activated cyclic nucleotide-gated (HCN) channel; an open channel blocker of neuronal Ih and related cardiac If channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 214 | Get Quote |
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| 10MG | 322 | Get Quote |
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| 25MG | 534 | Get Quote |
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| 50MG | 762 | Get Quote |
|
| 100MG | 1017 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCilobradine
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NoteResearch use only, not for human use.
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Brief DescriptionA hyperpolarization-activated cyclic nucleotide-gated (HCN) channel; an open channel blocker of neuronal Ih and related cardiac If channels.
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DescriptionA hyperpolarization-activated cyclic nucleotide-gated (HCN) channel; an open channel blocker of neuronal Ih and related cardiac If channels; strongly reduces the pacemaker diastolic depolarization rate and the cell's firing frequency.Ischemia Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsDK-AH 269 | DKAH-269
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PathwayMembrane Transporter/Ion Channel
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TargetHCN Channel
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RecptorHCN Channel
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Research AreaCardiovascular Disease
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IndicationIschemia
Chemical Information
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CAS Number186097-54-1
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Formula Weight519.0726
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Molecular FormulaC28H39ClN2O5
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCOC1=C(C=C(C=C1)CCN2CCCC(C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC.Cl
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Chemical Name2H-3-Benzazepin-2-one, 3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Van Bogaert PP, et al. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.
2. El-Kholy W,et al. Mol Endocrinol. 2007 Mar;21(3):753-64.
3. Cheng Y, et al. J Pharmacol Exp Ther. 2007 May;321(2):469-76.
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