Ciclesonide

Research use only, not for human use.

Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases.

Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases.(In Vitro):Ciclesonide, the parent compound, undergoes hydrolysis by ester cleavage at the C21 position to the active metabolite, desisobutyryl-ciclesonide (des-CIC), followed by reversible formation of fatty acid esters within the lung cells. Ciclesonide (5 μM) is rapidly hydrolyzed by normal human bronchial epithelial (NHBE) cells (approximately 30% conversion at 4h), with almost complete conversion by 24 h.

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RPR251526

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Inflammation/Immunology

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126544-47-6

540.69

C32H44O7

>98% (HPLC)

DMSO: 10 mM

CC(C)C(OCC([C@@]1([C@@]2(C)C[C@H](O)[C@]3([H])[C@@]4(C)C=C5)OC(C6CCCCC6)O[C@]1([H])C[C@@]2([H])[C@]3([H])CCC4=CC5=O)=O)=O

2-[(1S, 2S, 4R, 8S, 9S,11S, 12S, 13R)-6-cyclohexyl-11-hydroxy-9, 13-dimethyl-16-oxo-5, 7-dioxapentacyclo [10.8.0.02,9.04, 8.013,18] icosa-14, 17-dien-8-yl]- 2-oxoethyl 2-methylpropanoate

(-20℃)

With Ice Pack

≥ 2 years