Ciclesonide( RPR251526 )

Catalog No. M11111 CAS No. 126544-47-6

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HNMR

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Product Name

Ciclesonide
Note

Research use only, not for human use.
Brief Description

Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases.
Description

Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases.(In Vitro):Ciclesonide, the parent compound, undergoes hydrolysis by ester cleavage at the C21 position to the active metabolite, desisobutyryl-ciclesonide (des-CIC), followed by reversible formation of fatty acid esters within the lung cells. Ciclesonide (5 μM) is rapidly hydrolyzed by normal human bronchial epithelial (NHBE) cells (approximately 30% conversion at 4h), with almost complete conversion by 24 h.
In Vitro

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In Vivo

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Synonyms

RPR251526
Pathway

Endocrinology/Hormones
Target

GR
Recptor

Glucocorticoid Receptor
Research Area

Inflammation/Immunology
Indication

——

CAS Number

126544-47-6
Formula Weight

540.69
Molecular Formula

C32H44O7
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

CC(C)C(OCC([C@@]1([C@@]2(C)C[C@H](O)[C@]3([H])[C@@]4(C)C=C5)OC(C6CCCCC6)O[C@]1([H])C[C@@]2([H])[C@]3([H])CCC4=CC5=O)=O)=O
Chemical Name

2-[(1S, 2S, 4R, 8S, 9S,11S, 12S, 13R)-6-cyclohexyl-11-hydroxy-9, 13-dimethyl-16-oxo-5, 7-dioxapentacyclo [10.8.0.02,9.04, 8.013,18] icosa-14, 17-dien-8-yl]- 2-oxoethyl 2-methylpropanoate

1.Mutch E, et al. Biochem Pharmacol, 2007. 73(10): p. 1657-64.

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