Cart
sales@molnova.com
Fosdagrocorat
CAS No. 1044535-58-1
Fosdagrocorat( PF 04171327 )
Catalog No. M10220 CAS No. 1044535-58-1
Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 374 | In Stock |
|
| 50MG | 2232 | In Stock |
|
| 100MG | 3060 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFosdagrocorat
-
NoteResearch use only, not for human use.
-
Brief DescriptionFosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis.
-
DescriptionFosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat).Rheumatoid Arthritis Phase 2 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsPF 04171327
-
PathwayEndocrinology/Hormones
-
TargetGR
-
RecptorGR
-
Research AreaInflammation/Immunology
-
IndicationRheumatoid Arthritis
Chemical Information
-
CAS Number1044535-58-1
-
Formula Weight574.537
-
Molecular FormulaC29H30F3N2O5P
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (217.57 mM)
-
SMILESO=P(O)(O[C@@]1(C(F)(F)F)C[C@@]2([H])CCC3=C(C=CC(C(NC4=CC=CN=C4C)=O)=C3)[C@]2(CC5=CC=CC=C5)CC1)O
-
Chemical Name(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Stock T, et al. Int J Rheum Dis. 2017 Aug;20(8):960-970.
2. Miyoshi S, et al. Int J Clin Pharmacol Ther. 2016 Dec;54(12):966-976.
3. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.
molnova catalog
related products
-
Mometasone furoate
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways.
-
PF-04308515
PF-04308515 (PF 4308515) is a potent glucocorticoid receptor (GR) agonist with anti-inflammatory activity.
-
Fosdagrocorat
Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis.
