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Fosdagrocorat
CAS No. 1044535-58-1
Fosdagrocorat( PF 04171327 )
Catalog No. M10220 CAS No. 1044535-58-1
Fosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 374 | In Stock |
|
| 50MG | 2232 | In Stock |
|
| 100MG | 3060 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFosdagrocorat
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NoteResearch use only, not for human use.
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Brief DescriptionFosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis.
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DescriptionFosdagrocorat (PF 04171327) is an orally available, potential dissociated agonist of the glucocorticoid receptor (GR) for the treatment of rheumatoid arthritis, the phosphate ester prodrug of PF-00251802 (dagrocorat).Rheumatoid Arthritis Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPF 04171327
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PathwayEndocrinology/Hormones
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TargetGR
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RecptorGR
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number1044535-58-1
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Formula Weight574.537
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Molecular FormulaC29H30F3N2O5P
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (217.57 mM)
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SMILESO=P(O)(O[C@@]1(C(F)(F)F)C[C@@]2([H])CCC3=C(C=CC(C(NC4=CC=CN=C4C)=O)=C3)[C@]2(CC5=CC=CC=C5)CC1)O
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Chemical Name(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stock T, et al. Int J Rheum Dis. 2017 Aug;20(8):960-970.
2. Miyoshi S, et al. Int J Clin Pharmacol Ther. 2016 Dec;54(12):966-976.
3. Ripp SL, et al. Clin Pharmacol Drug Dev. 2017 Nov 7. doi: 10.1002/cpdd.411.
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