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Ch-319
CAS No.
Ch-319 ( Ch319 )
Catalog No. M17011 CAS No.
Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCh-319
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NoteResearch use only, not for human use.
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Brief DescriptionCh-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
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DescriptionCh-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer; reduces viability and induces cell cycle arrest associated with downregulation of PI3K and dephosphorylation of AKT and PRAS40 in PTEN-null PC3M and DU145 PCa cells at 250-500 nM; decreases tumor weights, reduces expression of androgen receptor, decreases phosphorylation of AKT and PRAS40 and increases FOXO3a in mice.
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SynonymsCh319
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight604.29
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Molecular FormulaC33H27NO3Sn
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Nametriphenylstannyl 2-(benzylcarbamoyl)benzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Durdana Waseem, et al. Abstract 688: Triphenylstannyl 2-(benzylcarbamoyl)benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. AACR.2018.
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