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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - (Z)-Guggulsterone

(Z)-Guggulsterone

CAS No. 39025-23-5

(Z)-Guggulsterone( —— )

Catalog No. M24353 CAS No. 39025-23-5

(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 118 In Stock
25MG 235 In Stock
50MG 352 In Stock
100MG 528 In Stock
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Biological Information

  • Product Name
    (Z)-Guggulsterone
  • Note
    Research use only, not for human use.
  • Brief Description
    (Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
  • Description
    (Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
  • In Vitro
    Western Blot Analysis Cell Line:Vascular endothelial growth factor (VEGF)Concentration:10, 20 μM Incubation Time:24 or 48 hours Result:Caused a decrease in the level of VEGF-R2 protein in HUVEC.
  • In Vivo
    Animal Model:Male nude mice(5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage:1 mg Administration:Oral; 5 times/week Result:Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt|VEGF-R2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    39025-23-5
  • Formula Weight
    312.45
  • Molecular Formula
    C21H28O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mg/mL?(32.01 mM;?ultrasonic and warming and heat to 60°C)
  • SMILES
    C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.
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