Cerevisterol
CAS No. 516-37-0
Cerevisterol ( —— )
Catalog No. M29031 CAS No. 516-37-0
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCerevisterol
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NoteResearch use only, not for human use.
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Brief DescriptionCerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
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DescriptionCerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. Cerevisterol acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-κB, AP-1, and Nrf2-mediated HO-1 signaling cascade.(In Vitro):Cerevisterol suppresses the LPS-induced production of NO and PGE2, which is a plausible mechanism for this effect is by reducing the expression of iNOS and COX-2. Cerevisterol also decreases the expression of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β. Cerevisterol halted the nuclear translocation of NF-κB by blocking the phosphorylation of inhibitory protein κBα (IκBα) and suppressing NF-κB transactivation. The mitogen-activated protein kinases (MAPK) signaling pathways are also suppressed. Cerevisterol treatment also inhibited the transactivation of AP-1 and the phosphorylation of c-Fos. Furthermore, Cerevisterol could induce the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) by down-regulating Kelch-like ECH-associated protein 1 (Keap-1) and up-regulating hemeoxygenases-1 (HO-1) expression.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number516-37-0
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Formula Weight430.7
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Molecular FormulaC28H46O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)[C@@H](C)/C=C/[C@@H](C)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@H](C3)O)[C@@]33O)[C@@H]1C2=C[C@H]3O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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