Cerevisterol

CAS No. 516-37-0

Cerevisterol ( —— )

Catalog No. M29031 CAS No. 516-37-0

Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cerevisterol
  • Note
    Research use only, not for human use.
  • Brief Description
    Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
  • Description
    Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. Cerevisterol acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-κB, AP-1, and Nrf2-mediated HO-1 signaling cascade.(In Vitro):Cerevisterol suppresses the LPS-induced production of NO and PGE2, which is a plausible mechanism for this effect is by reducing the expression of iNOS and COX-2. Cerevisterol also decreases the expression of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β. Cerevisterol halted the nuclear translocation of NF-κB by blocking the phosphorylation of inhibitory protein κBα (IκBα) and suppressing NF-κB transactivation. The mitogen-activated protein kinases (MAPK) signaling pathways are also suppressed. Cerevisterol treatment also inhibited the transactivation of AP-1 and the phosphorylation of c-Fos. Furthermore, Cerevisterol could induce the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) by down-regulating Kelch-like ECH-associated protein 1 (Keap-1) and up-regulating hemeoxygenases-1 (HO-1) expression.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    516-37-0
  • Formula Weight
    430.7
  • Molecular Formula
    C28H46O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@H](C3)O)[C@@]33O)[C@@H]1C2=C[C@H]3O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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