CeMMEC1 ( CeMMEC 1 )

Catalog No. M14499 CAS No. 440662-09-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CeMMEC1
Note

Research use only, not for human use.
Brief Description

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM.
Description

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM; shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM; impaires cell viability in TAF1 downregulated cells; synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.
Synonyms

CeMMEC 1
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD4;TAF1
Research Area

——
Indication

——

CAS Number

440662-09-9
Formula Weight

336.30
Molecular Formula

C19H16N2O4
Purity

>98% (HPLC)
Solubility

DMSO: 21 mg/mL (62.4 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CN1C=C(C2=CC=CC=C2C1=O)C(=O)NC3=CC4=C(C=C3)OCCO4
Chemical Name

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide

1. Sdelci S, et al. Nat Chem Biol. 2016 Jul;12(7):504-10.

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