Carabrone

Research use only, not for human use.

Carabrone, a botanical bicyclic sesquiterpenic lactone, is a promising fungicidal agent that can effectively control G. tritici.

Carabrone, a botanical bicyclic sesquiterpenic lactone, is a promising fungicidal agent that can effectively control G. tritici.(In Vitro):The silenced mutant ?GtIsp is less sensitive to carabrone compared to ?GtCytc1 and ?GtCytb. Compared with the control, the activities of complex III in all the strains, except ?GtIsp and carabrone-resistant isolate 24-HN-1, were significantly decreased following treatment with carabrone at EC20 and EC80 in vitro (40%-50% and 70%-80%, respectively). The activities of mitochondrial respiratory chain complex III and the mitochondrial respiration oxygen consumption rates in all the strains, except ?GtIsp and 24-HN-1, were higher with respect to the control when treated with carabrone at EC20 in vivo. The rates of mitochondrial respiration of all strains, except ?GtIsp, were significantly inhibited following treatment with carabrone at EC80 (ranging from 57% to 81%).

——

GPCR/G Protein

Antibacterial

Antibacterial

——

——

1748-81-8

248.3

C15H20O3

>98% (HPLC)

——

CC(=O)CC[C@H]1[C@@H]2C[C@H]3[C@@H](C[C@]12C)OC(=O)C3=C

——

(-20℃)

With Ice Pack

≥ 2 years