Capsaicin
CAS No. 404-86-4
Capsaicin( Capsicine | Capsicin | trans8MethylNvanillylnon6enamide | (E)Capsaicin )
Catalog No. M14387 CAS No. 404-86-4
Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 45 | In Stock |
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| 100MG | 68 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCapsaicin
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NoteResearch use only, not for human use.
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Brief DescriptionCapsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel.
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DescriptionCapsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open below 37 °C This is why capsaicin is linked to the sensation of heat. (In Vitro):Capsaicin is the main Capsaicinoid in chili peppers, followed by Dihydrocapsaicin. These two compounds provide about twice hotness to the taste and nerves as the minor capsaicinoids.
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In Vitro——
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In Vivo——
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SynonymsCapsicine | Capsicin | trans8MethylNvanillylnon6enamide | (E)Capsaicin
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorhTRPV1( in HEK293 cell)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number404-86-4
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Formula Weight305.41
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Molecular FormulaC18H27NO3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 44 mg/mL
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SMILESCC(C)/C=C/CCCCC(NCC1=CC=C(O)C(OC)=C1)=O
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Chemical Name8-Methyl-N-vanillyl-(trans)-6-nonenamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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GSK2193874
GSK2193874 was identified as a selective orally active TRPV4 blocker.
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Pyr6
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?
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AC1903
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?
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