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Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - AC1903

AC1903

CAS No. 831234-13-0

AC1903 ( —— )

Catalog No. M22075 CAS No. 831234-13-0

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AC1903
  • Note
    Research use only, not for human use.
  • Brief Description
    AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?
  • Description
    AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPC5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    831234-13-0
  • Formula Weight
    303.36
  • Molecular Formula
    C19H17N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(NC1=NC2=CC=CC=C2N1CC1=CC=CC=C1)C1=CC=CO1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sharma S H , Pablo J L , Montesinos M S , et al. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903[J]. Bioorganic & Medicinal Chemistry Letters, 2018.
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