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CX4152
CAS No. 333351-27-2
CX4152( CX 4152 | CX-4152 )
Catalog No. M14121 CAS No. 333351-27-2
A novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameCX4152
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM.
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DescriptionA novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM; displays>1,000-fold selectivity over CXCR4 (IC50>50 uM); inhibits CXCR2 signaling through downregulation of surface CXCR2; significantly inhibits CXCL8-mediated neutrophil migration and LPS-induced lung inflammation in mice; inhibits CXCR2/β-arrestin-2 association, cell migration and proliferation, and acute inflammation in mouse models.
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In Vitro——
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In Vivo——
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SynonymsCX 4152 | CX-4152
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number333351-27-2
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Formula Weight435.538
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Molecular FormulaC25H25NO4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C2=C(O1)C3=CC=CC=C3C(=C2)NS(=O)(=O)C4=CC=C(C=C4)C(C)(C)C)C(=O)C
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Chemical NameN-(3-acetyl-2-methylnaphtho[1,2-b]furan-5-yl)-4-(tert-butyl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ha H, et al. J Chem Inf Model. 2015 Aug 24;55(8):1720-38.
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