CX797( CX-797 | CX 797 )

Catalog No. M12334 CAS No. 1611496-70-8

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Product Name

CX797
Note

Research use only, not for human use.
Brief Description

A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
Description

A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM; inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment; also inhibits IL8-mediated cell migration.
In Vitro

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In Vivo

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Synonyms

CX-797 | CX 797
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

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CAS Number

1611496-70-8
Formula Weight

382.5
Molecular Formula

C19H18N4OS2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1CCCC2=C1C3=C(S2)N4C(=NN=C4SC)N(C3=O)C5=CC=CC=C5
Chemical Name

(R)-6-methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one

1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.

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