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CWP-232228

CAS No. ——

CWP-232228( CWP232228 )

Catalog No. M16979 CAS No. ——

CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CWP-232228
  • Note
    Research use only, not for human use.
  • Brief Description
    CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.
  • Description
    CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus; preferentially inhibits the growth of breast cancer stem cells (BCSC) as well as bulk tumor cells; inhibits β-catenin-mediated transcription and attenuates IGF-I-mediated BCSC functions; reduces tumor growth in a murine xenograft model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CWP232228
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Beta-catenin
  • Recptor
    Beta-catenin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    717.63
  • Molecular Formula
    C33H36N7O7P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2,3-dihydrocinnolin-8-yl)methyl)-4,7-dioxooctahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jang GB, et al. Cancer Res. 2015 Apr 15;75(8):1691-702. 2. Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409. 3. Benoit YD, et al. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9.
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