CWHM-12 ( CWHM12; CWHM 12; CWHM-12. )

Catalog No. M12231 CAS No. 1564286-55-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CWHM-12
Note

Research use only, not for human use.
Brief Description

A novel active RGD peptidomimetic inhibitor of αv integrin with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8; no inhibition on αIIbβ3, α2β1 and α10β1 (>50 uM).
Description

A novel active RGD peptidomimetic inhibitor of αv integrin with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8; no inhibition on αIIbβ3, α2β1 and α10β1 (>50 uM); significantly inhibits progression of pulmonary fibrosis in mice model.Cystic Fibrosis Preclinical
Synonyms

CWHM12; CWHM 12; CWHM-12.
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Other Indications
Indication

Fibrosis

CAS Number

1564286-55-0
Formula Weight

590.47
Molecular Formula

C26H32BrN5O6
Purity

>98% (HPLC)
Solubility

DMSO: 10.5 mg/mL
SMILES

OC1=CC(C(NCC(N[C@@H](CC(O)=O)C2=CC(Br)=CC(C(C)(C)C)=C2)=O)=O)=CC(NC3=NCC(O)CN3)=C1
Chemical Name

β-Alanine, N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-, (3S)-

1. Henderson NC, et al. Nat Med. 2013 Dec;19(12):1617-24.
2. Ulmasov B, et al. Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518.

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