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Home - Products - Cell Cycle/DNA Damage - Integrin - TR-14035

TR-14035

CAS No. 232271-19-1

TR-14035 ( TR 14035;TR14035 )

Catalog No. M13660 CAS No. 232271-19-1

A potent, orally bioavailable, dual α4β7/α4β1 integrin antagonist with IC50 of 7/87 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TR-14035
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally bioavailable, dual α4β7/α4β1 integrin antagonist with IC50 of 7/87 nM.
  • Description
    A potent, orally bioavailable, dual α4β7/α4β1 integrin antagonist with IC50 of 7/87 nM; blocks the binding of human α4β7 to an (125)I-MAdCAM-Ig fusion protein with IC50 of 0.75 nM; suppresses antigen-induced lung interleukin (IL)-5 mRNA upregulation, inhibits the leukocyte rolling flux, adhesion and emigration induced by IL4 in rats.Asthma Phase 1 Discontinued
  • Synonyms
    TR 14035;TR14035
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    α4β7integrin;α4β1integrin
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    232271-19-1
  • Formula Weight
    474.33
  • Molecular Formula
    C24H21Cl2NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO：≥ 41 mg/mL
  • SMILES
    O=C(O)[C@H](CC1=CC=C(C2=C(OC)C=CC=C2OC)C=C1)NC(C3=C(Cl)C=CC=C3Cl)=O
  • Chemical Name
    [1,1'-Biphenyl]-4-propanoic acid, α-[(2,6-dichlorobenzoyl)amino]-2',6'-dimethoxy-,(αS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sircar I, et al. Bioorg Med Chem. 2002 Jun;10(6):2051-66.
2. Cortijo J, et al. Br J Pharmacol. 2006 Mar;147(6):661-70.
3. Tsuda-Tsukimoto M, et al. Pharm Res. 2006 Nov;23(11):2646-56.
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