Cilengitide ( EMD 121974 )

Catalog No. M12961 CAS No. 188968-51-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Cilengitide
Note

Research use only, not for human use.
Brief Description

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Description

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Synonyms

EMD 121974
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

αVβ3 integrin; αVβ5 integrin
Research Area

Cancer
Indication

——

CAS Number

188968-51-6
Formula Weight

588.66
Molecular Formula

C27H40N8O7
Purity

>98%(HPLC)
Solubility

Water: 8 mg/mL (13.59 mM); DMSO: 100 mg/mL (169.87 mM)
SMILES

CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
Chemical Name

——

1.Reardon DA, et al. Genes Y, 2011, 2(12):1159-1165.

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