
CSLP43
CAS No. 2244988-80-3
CSLP43( RIPK2 inhibitor CSLP43 )
Catalog No. M13601 CAS No. 2244988-80-3
CSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay.
Purity : >98% (HPLC)






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Biological Information
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Product NameCSLP43
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NoteResearch use only, not for human use.
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Brief DescriptionCSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay.
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DescriptionCSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling; exhibits inhibition of TNF release from RAW264.7 cells with EC50 of 1.2 nM, inhibits NF-κB reporter activity with IC50 of 1.34 nM; antagonizes NOD2 signaling by interfering with the XIAP-RIPK2 interaction, selectively inhibits NOD responses in cells (HEKBlue NOD2 IC50=1.3 nM) and displays potent activity in vivo, does not attenuates the TNF release following an unrelated pro-inflammatory stimulation mediated through TLR4 activation by LPS at 1 uM.
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In Vitro——
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In Vivo——
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SynonymsRIPK2 inhibitor CSLP43
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number2244988-80-3
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Formula Weight511.641
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Molecular FormulaC26H33N5O4S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(5-(2-amino-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)-2,3-dimethoxyphenyl)propane-1-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hrdinka M, et al. EMBO J. 2018 Jul 19. pii: e99372.
molnova catalog



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