RIPGBM( —— )

Catalog No. M14216 CAS No. 355406-76-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RIPGBM
Note

Research use only, not for human use.
Brief Description

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).
Description

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells); RIPGBM is converted to an apoptosis-inducing derivative (cRIPGBM/RIPGBM-18) selectively in GBM CSCs; cRIPGBM induces apoptosis in GBM CSCs by interacting with RIPK2; significantly suppress tumor formation in vivo in orthotopic intracranial GBM CSC tumor xenograft mouse model.
In Vitro

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex.
In Vivo

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Synonyms

——
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

——
Indication

——

CAS Number

355406-76-7
Formula Weight

428.463
Molecular Formula

C26H21FN2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (77.79 mM)
SMILES

CC(=O)N(CC1=CC=C(C=C1)F)C2=C(C(=O)C3=CC=CC=C3C2=O)NCC4=CC=CC=C4
Chemical Name

N-(3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

1. Lucki NC, et al. Proc Natl Acad Sci U S A. 2019 Mar 7. pii: 201816626. doi: 10.1073/pnas.1816626116.

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