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CS-0777
CAS No. 827344-05-8
CS-0777( CS 0777 | CS0777 )
Catalog No. M16073 CAS No. 827344-05-8
A potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCS-0777
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.
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DescriptionA potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3; significantly decreases lymphocyte counts at doses of 0.1 and 1 mg/kg in rats, demonstrates potential benefits in the treatment of autoimmune diseases.Multiple Sclerosis Phase 3 Clinical
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In Vitro——
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In Vivo——
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SynonymsCS 0777 | CS0777
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PathwayGPCR/G Protein
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TargetLysophospholipid Receptor
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RecptorLysophospholipid Receptor
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number827344-05-8
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Formula Weight342.483
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Molecular FormulaC21H30N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=C(C=C1)CCCC(=O)C2=CC=C(N2C)CCC(C)(CO)N
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Chemical Name(R)-1-(5-(3-amino-4-hydroxy-3-methylbutyl)-1-methyl-1H-pyrrol-2-yl)-4-(p-tolyl)butan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nishi T, et al. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72.
2. Yonesu K, et al. J Biol Chem. 2011 Jul 15;286(28):24765-75.
3. Moberly JB, et al. J Neuroimmunol. 2012 May 15;246(1-2):100-7.
4. Inaba S, et al. Xenobiotica. 2015;45(12):1063-80.
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