CPI703 ( CPI-703;CPI 703 )

Catalog No. M12987 CAS No. 1904649-00-8

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Product Name

CPI703
Note

Research use only, not for human use.
Brief Description

A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP.
Description

A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP; displays little to no (>200-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM); inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 2.1 uM, reduces Treg differentiation and exhibits FOXP3 inhibition with IC50 of 1.5 uM, significantly affects TH17 differentiation, suppresses TH17 cytokines, IL-17A, IL-17F, and IL-21 with no effect on TNFα production or cell viability.
Synonyms

CPI-703;CPI 703
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1904649-00-8
Formula Weight

298.39
Molecular Formula

C17H22N4O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C[C@@H](C)NC2=C(C3=CN(C(C)(C)C)N=C3)C=CC=C2N1
Chemical Name

(R)-6-(1-(tert-butyl)-1H-pyrazol-4-yl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one

1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

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