FL-411 ( FL411 )

Catalog No. M13371 CAS No. 2118944-88-8

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HNMR

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Product Name

FL-411
Note

Research use only, not for human use.
Brief Description

FL-411 is a novel small-molecule inhibitor of BRD4.
Description

FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells; induces ACD pathways involved in HMGB1, VDAC1/2, and eEF2, displays a therapeutic potential on both breast cancer xenograft mouse and zebrafish models.
Synonyms

FL411
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD4
Research Area

Cancer
Indication

——

CAS Number

2118944-88-8
Formula Weight

341.43
Molecular Formula

C18H19N3O2S
Purity

>98% (HPLC)
Solubility

（ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CC1=CC(=CC(=C1O)C)C2=NC3=C(C4=C(S3)CN(CC4)C)C(=O)N2
Chemical Name

2-(4-Hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

1. Ouyang L, et al. J Med Chem. 2017 Dec 28;60(24):9990-10012.

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