CK-37

CAS No. 1001478-90-5

CK-37( ChoK-α inhibitor CK37 )

Catalog No. M10017 CAS No. 1001478-90-5

A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CK-37
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.
  • Description
    A potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62; suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling; significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ChoK-α inhibitor CK37
  • Pathway
    Others
  • Target
    ChoK
  • Recptor
    ChoK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1001478-90-5
  • Formula Weight
    366.483
  • Molecular Formula
    C20H22N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC1=CC=C(C=C1)C2=NC(=NN2)SCC(=O)NC3=CC(=CC(=C3)C)C
  • Chemical Name
    N-(3,5-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl] acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clem BF, et al. Oncogene. 2011 Jul 28;30(30):3370-80. 2. Kim HS, et al. PLoS One. 2015 Oct 23;10(10):e0141110. 3. Wong MT, et al. J Virol. 2016 Sep 29;90(20):9075-95.
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