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MN58b

CAS No. 203192-01-2

MN58b( MN-58b | MN 58b )

Catalog No. M13164 CAS No. 203192-01-2

MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MN58b
  • Note
    Research use only, not for human use.
  • Brief Description
    MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM.
  • Description
    MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism; demonstrates antiproliferative properties against human tumor-derived cell lines (HT29 IC50=0.5 uM) and antitumor activity against human tumor xenografts in vivo.
  • In Vitro
    Cell Viability Assay Cell Line:SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration:1 μM, 5 μM Incubation Time:72 hours Result:Inhibited cells growth.Apoptosis Analysis Cell Line:SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells Concentration:1 μM, 2 μM, 5 μM, 10 μM Incubation Time:24 and 48 hoursResult:Induced cell apoptosis.
  • In Vivo
    Animal Model:MF-1 nude mice with HT29 or MDA-MB-231 cells Dosage:4 mg/kg Administration:Intraperitoneal injection; once a day; for 5 daysResult:Phosphomonoesters decreased significantly.
  • Synonyms
    MN-58b | MN 58b
  • Pathway
    Others
  • Target
    ChoK
  • Recptor
    ChoK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    203192-01-2
  • Formula Weight
    640.508
  • Molecular Formula
    C32H40Br2N4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 14.71 mg/mL (22.97 mM)
  • SMILES
    ——
  • Chemical Name
    1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9. 2. Hernández-Alcoceba R, et al. Cancer Res. 1999 Jul 1;59(13):3112-8. 3. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34. 4. Guma M, et al. Ann Rheum Dis. 2015 Jul;74(7):1399-407.
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