Cart
sales@molnova.com
Home - Products - Angiogenesis - Bcl-2 - A-1155463

A-1155463

CAS No. 1235034-55-5

A-1155463 ( A1155463;A 1155463 )

Catalog No. M10940 CAS No. 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 80 In Stock
10MG 132 In Stock
25MG 248 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    A-1155463
  • Note
    Research use only, not for human use.
  • Brief Description
    A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).
  • Description
    A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM); shows >1000-fold weaker binding to BCL-2, BCL-W (Ki =19 nM) and MCL-1 (Ki >440 nM); inhibits H146 SCLC xenograft tumor growth in vivo.
  • Synonyms
    A1155463;A 1155463
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-xL;Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1235034-55-5
  • Formula Weight
    669.79
  • Molecular Formula
    C35H32FN5O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
  • Chemical Name
    4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tao ZF, et al. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93.
2. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.
3. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • HA14-1

    HA14-1 a small molecule, nonpeptidic Bcl-2 antagonist that binds Bcl-2 surface pocket with binding IC50 of 9 uM.

  • BI-3802

    BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

  • Apogossypol

    Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively.

Sign In Join Free