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A-1155463

CAS No. 1235034-55-5

A-1155463 ( A1155463;A 1155463 )

Catalog No. M10940 CAS No. 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A-1155463
  • Note
    Research use only, not for human use.
  • Brief Description
    A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).
  • Description
    A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM); shows >1000-fold weaker binding to BCL-2, BCL-W (Ki =19 nM) and MCL-1 (Ki >440 nM); inhibits H146 SCLC xenograft tumor growth in vivo.
  • Synonyms
    A1155463;A 1155463
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-xL;Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1235034-55-5
  • Formula Weight
    669.79
  • Molecular Formula
    C35H32FN5O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
  • Chemical Name
    4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tao ZF, et al. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93.
2. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.
3. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.
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