CFT7455
CAS No. 2504235-67-8
CFT7455 ( —— )
Catalog No. M28495 CAS No. 2504235-67-8
CFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 295 | Get Quote |
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10MG | 484 | Get Quote |
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25MG | 781 | Get Quote |
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50MG | 1062 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameCFT7455
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NoteResearch use only, not for human use.
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Brief DescriptionCFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).
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DescriptionCFT7455 is an anti-cancer agent showing high affinity to the cereblon E3 ligase with a Kd of 0.9 nM. CFT7455 is an orally active degrader of zinc finger transcription factors Ikaros (IKZF1), and Aiolos (IKZF3).(In Vitro):CFT7455 enables potent cell growth inhibition in both previously untreated NCIH929 multiple myeloma cell lines with an IC50 of 0.071 nM and NCIH929 cells made resistant to both lenalidomide and pomalidomide with an IC50 of 2.3 nM. CFT7455 promotes the degradation of >75% of steady state IKZF1 in multiple myeloma cells within 1.5 hours at 0.3 nM.(In Vivo):In mouse xenograft tumor models, CFT7455 (3 μg/kg-100 μg/kg) led to durable tumor regression and demonstrates dose-dependent efficacy.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPDE3
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Research Area——
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Indication——
Chemical Information
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CAS Number2504235-67-8
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Formula Weight469.5
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Molecular FormulaC28H27N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=C3C(C(CC4=CC=C(CN5CCOCC5)C=C4)=CC=C3N1[C@@H](CCC6=O)C(N6)=O)=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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