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Arazine
CAS No. 135304-07-3
Arazine( N-Acetyl-S-farnesyl-L-cysteine )
Catalog No. M26060 CAS No. 135304-07-3
Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 231 | In Stock |
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| 10MG | 341 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameArazine
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NoteResearch use only, not for human use.
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Brief DescriptionArazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.
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DescriptionArazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.(In Vitro):Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.(In Vivo):Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl.
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In VitroArazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner inHMEC-1 cell.Arazine (10–100 μM;8 hours)significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion inHMEC-1 cell.
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In VivoArazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl. Animal Model:TPA-induced ear acute inflammation in mouse Dosage:2000?μg/20?μl Administration:2000?μg/20?μl; Applied on ear Result:Inhibited ear edema, as measured by ear weight.
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SynonymsN-Acetyl-S-farnesyl-L-cysteine
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PathwayOthers
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TargetOther Targets
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RecptorS1PR4
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Research Area——
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Indication——
Chemical Information
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CAS Number135304-07-3
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Formula Weight367.55
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Molecular FormulaC20H33NO3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Guerrero M,et,al.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.
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