CD437 ( CD437; CD 437; CD-437; Ro-472077 )

Catalog No. M17220 CAS No. 125316-60-1

CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.

Purity : 98%

COA

Datasheet

HNMR

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Size	Price / USD	Stock	Quantity
2MG	31	In Stock
5MG	50	In Stock
10MG	80	In Stock
25MG	170	In Stock
50MG	282	In Stock
100MG	462	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

CD437
Note

Research use only, not for human use.
Brief Description

CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
Description

CD437 is a synthetic retinoid that is an RARγ-selective agonist. It displays RARγ-dependent and -independent effects on differentiation and apoptosis. CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma. CD437 inhibits DNA replication in cells and recombinant POLA1 activity in vitro.
Synonyms

CD437; CD 437; CD-437; Ro-472077
Pathway

Microbiology/Virology
Target

HBV
Recptor

RARγ
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

125316-60-1
Formula Weight

398.49
Molecular Formula

C27H26O3
Purity

98%
Solubility

DMSO : 150 mg/mL. 376.42 mM;
SMILES

O=C(C1=CC=C2C=C(C3=CC=C(O)C(C4(C5)CC6CC5CC(C6)C4)=C3)C=CC2=C1)O
Chemical Name

6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Li Y, et al. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol Cell Biol. 1998 Aug;18(8):4719-31.

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