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CCT128930
CAS No. 885499-61-6
CCT128930 ( CCT 128930;CCT-128930 )
Catalog No. M16409 CAS No. 885499-61-6
CCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 59 | In Stock |
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| 5MG | 104 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 368 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 779 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCCT128930
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NoteResearch use only, not for human use.
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Brief DescriptionCCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2).
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DescriptionCCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2), 28-fold selectivity over the closely related PKA; also exhibits 20-fold selectivity over p70S6K (IC50=120 nM); shows growth inhibition for U87MG human glioblastoma cells (IC50=6.3 uM), for LNCaP human prostate cancer cells (IC50=0.35 uM), and for PC3 human prostate cancer cells (IC50=1.9 uM) consistent with AKT pathway blockade; blocks the phosphorylation of several downstream AKT biomarkers in U87MG tumor xenografts, indicating AKT inhibition in vivo; demonstrates antitumor activity in U87MG and HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts.
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SynonymsCCT 128930;CCT-128930
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt2 , p70 S6K , PKA
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number885499-61-6
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Formula Weight341.80
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Molecular FormulaC18H20ClN5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESNC1(CC2=CC=C(Cl)C=C2)CCN(C3=C4C(NC=C4)=NC=N3)CC1
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Chemical Name4-Piperidinamine, 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Caldwell JJ, et al. J Med Chem. 2008 Apr 10;51(7):2147-57.
2. Yap TA, et al. Mol Cancer Ther. 2011 Feb;10(2):360-71.
3. Yap TA, et al. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.
2. Yap TA, et al. Mol Cancer Ther. 2011 Feb;10(2):360-71.
3. Yap TA, et al. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.
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