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PHT-427

CAS No. 1191951-57-1

PHT-427 ( PHT 427;PHT427 )

Catalog No. M10660 CAS No. 1191951-57-1

PHT-427 is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PHT-427
  • Note
    Research use only, not for human use.
  • Brief Description
    PHT-427 is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM.
  • Description
    PHT-427 is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM, inhibits phospho-Ser473-AKT in Panc-1 cells with IC50 of 6.3 uM; decreases AKT activation and causes apoptosis at low micromolar concentrations in Panc-1 and MiaPaCa-2 pancreatic cancer cell lines; inhibits AKT and its downstream targets in cells, exhibits good antitumor activity in pancreatic cancer cell xenografts in immunocompromised mice.
  • Synonyms
    PHT 427;PHT427
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt;PDK1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1191951-57-1
  • Formula Weight
    409.61
  • Molecular Formula
    C20H31N3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=C(CCCCCCCCCCCC)C=C1)(NC2=NN=CS2)=O
  • Chemical Name
    Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Moses SA, et al. Cancer Res. 2009 Jun 15;69(12):5073-81.
2. Meuillet EJ, et al. Mol Cancer Ther. 2010 Mar;9(3):706-17.
3. Dickinson SE, et al. Cancer Prev Res (Phila). 2016 Mar;9(3):215-24.
4. Kobes JE, et al. Pancreas. 2016 Sep;45(8):1158-66.
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