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CCG-224406

CAS No. 1870843-22-3

CCG-224406( CCG 224406 | CCG224406 )

Catalog No. M12895 CAS No. 1870843-22-3

A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CCG-224406
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM.
  • Description
    A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM; displays >700-fold selectivity over other GRK subfamilies, and no detectable inhibition of ROCK1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CCG 224406 | CCG224406
  • Pathway
    Others
  • Target
    GRK (GPCRK)
  • Recptor
    GRK (GPCRK)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1870843-22-3
  • Formula Weight
    558.57
  • Molecular Formula
    C29H27FN6O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC(C2=CC=C(F)C(C(NCC3=C(OC)C=CC=C3OC)=O)=C2)C(C(NC4=CC5=C(C=C4)NN=C5)=O)=C(C)N1
  • Chemical Name
    4-(3-((2,6-dimethoxybenzyl)carbamoyl)-4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.
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