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CBR-5884
CAS No. 681159-27-3
CBR-5884 ( —— )
Catalog No. M22643 CAS No. 681159-27-3
CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 87 | In Stock |
|
| 25MG | 205 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCBR-5884
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NoteResearch use only, not for human use.
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Brief DescriptionCBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
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DescriptionCBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.?Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDHCBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits breast cancer lines that have a high propensity for serine synthesis. CBR-5884 (15 or 30 μM; 3-5 days) also selectively inhibits the proliferation of melanoma.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorPHGDH;serine synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number681159-27-3
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Formula Weight336.39
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Molecular FormulaC14H12N2O4S2
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Purity>98% (HPLC)
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SolubilityDMSO:47 mg/mL (139.72 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.
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CBR-5884
CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
