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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - CBP-IN-1

CBP-IN-1

CAS No. 2222941-37-7

CBP-IN-1( —— )

Catalog No. M22843 CAS No. 2222941-37-7

CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CBP-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
  • Description
    CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Noncastrated male athymic nude mice Dosage:10-30 mg/kg Administration:Oral gavage; at 10 or 20 mg/kg daily (QD) or at 30 mg/kg every other day (QOD) for 28 days Result:Affected tumor growth at 10 mg/kg daily, 20 mg/kg daily, and 30 mg/kg every other day.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    p300/CBP
  • Research Area
    cancer
  • Indication
    Haematological Malignancy|Acute Myeloid Leukemia|Non Hodgkin Lymphoma|Multiple Myeloma

Chemical Information

  • CAS Number
    2222941-37-7
  • Formula Weight
    534.6
  • Molecular Formula
    C30H32F2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (187.06 mM; Need ultrasonic)
  • SMILES
    O=C1N(C2=CC=C(F)C(F)=C2)[C@H](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@H](OC)CC6)CCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neil Anthony Pegg, et al. Pharmaceutical compounds. WO2018073586A1.
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