C-82( —— )

Catalog No. M26079 CAS No. 1422253-37-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

C-82
Note

Research use only, not for human use.
Brief Description

C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
Description

C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.(In Vitro):C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs.(In Vivo):PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

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Research Area

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Indication

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CAS Number

1422253-37-9
Formula Weight

578.673
Molecular Formula

C33H34N6O4
Purity

>98% (HPLC)
Solubility

——
SMILES

[H][C@]12[C@H](C)N(Cc3cccc4cccnc34)C(=O)[C@H](Cc3ccc(O)cc3)N1C(=O)CN(C)N2C(=O)NCc1ccccc1
Chemical Name

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1.Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

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