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C-178
CAS No. 329198-87-0
C-178( —— )
Catalog No. M20739 CAS No. 329198-87-0
C-178 is a covalent inhibitor of STING binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
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| 5MG | 53 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 177 | In Stock |
|
| 50MG | 282 | In Stock |
|
| 100MG | 444 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameC-178
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NoteResearch use only, not for human use.
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Brief DescriptionC-178 is a covalent inhibitor of STING binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
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DescriptionC-178 is a covalent inhibitor of STING binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
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In VitroWestern Blot Analysis Cell Line:Mouse bone marrow-derived macrophages (BMDMs)Concentration:0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM Incubation Time:1 hour Result:Inhibited CMA-induced p-TBK1 expression as a does dependent manner.RT-PCR Cell Line:Mouse bone marrow-derived macrophages (BMDMs)Concentration:1 μM Incubation Time:1 hour Result:Downregulated Ifnb1 expression in BMDMs.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetSTING
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RecptormSTING
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Research Area——
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Indication——
Chemical Information
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CAS Number329198-87-0
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Formula Weight322.27
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Molecular FormulaC17H10N2O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (129.30 mM)
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SMILES[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2c(c1)oc1ccccc21
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Chemical NameN-(Dibenzo[bd]furan-3-yl)-5-nitrofuran-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Haag S M Gulen M F Luc R et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature 2018.
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